Post Doctoral Associate - Surgery
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The Department of Surgery has an exciting opportunity for a Full Time Post Doctoral Associate. The Datta laboratory focuses on understanding how myeloid-derived suppressor cells regulate stromal inflammation and novel mechanism of T-cell dysfunction in pancreatic cancer utilizing in silico , in vitro and in vivo techniques. Moreover, we are a highly translational laboratory, with the express goal of leveraging these preclinical discoveries to develop immunotherapeutic strategies to reprogram the suppressive immune microenvironment in pancreatic cancer. We are looking for a postdoctoral fellow with a background in tumor immunology and/or cancer biology, with a particular interest in innate immunity, translational immunogenomics, and pancreatic cancer. The candidate will have access to several platforms working with pancreas/GI cancer patient-derived models, including Hyperion imaging cytometry, single-cell RNA sequencing data in human tumors and PBMCs, RNA-seq/whole transcriptome sequencing data from patients’ tumors, and novel in vivo models investigating MDSC biology and its crosstalk with diverse cellular compartments in the pancreatic tumor microenvironment. We have multiple collaborations with pharma companies and are investigating several novel drugs with significant translational promise. Most importantly, our preclinical data translates to clinical trials at Sylvester – the candidate will have a unique opportunity to understand the bench-to-bedside model of cancer research. The Post Doctoral Associate performs scientific research and studies under the supervision of managing staff. Moreover, the Post Doctoral Associate promotes institutional recognition through literal contributions to the scientific community.
Requires the ability to effectively and creatively perform cancer immunology research and take responsibility for assuring quality, cost effectiveness, and timeliness for projects while working under the limited supervision of the PI and/or senior members of the laboratory.
Work with animals, as well as animal and human cells/tissues.
Maintain mouse colonies
Perform immunologic assays (e.g., cytotoxicity assays, myeloid migration studies, immune activity assays, ex vivo co-culture studies, etc.)
Perform flow cytometry
Perform immunohistochemistry and immunofluorescence.
Perform and maintain tissue and cell culture.
Develop project proposals in line with research strategy.
Rigorously document and maintain a record of research findings.
Maintain appropriate databases. Ensure accurate written and computerized records.
Effectively communicate and present results.
Prepare research results for public presentation through seminars and conferences.
Undertakes literature searches for the research project. Interpret and present the findings of the literature searches, advising the research teams appropriately regarding potential projects.
Maintain up to date knowledge of subject, experimental, and professional related issues.
Ensure all research is undertaken according to good research practice and guidance.
Performs other duties as assigned.
Conducts research on specific areas of study as assigned.
- Prepares research reports and technical papers for publishing.
- Investigates the feasibility of applying a wide variety of scientific principles and theories.
- Maintains substantial knowledge of state-of-the-art principles and theories.
- Develops advanced analytical models and systems and provides solutions and analyses to support strategic and tactical decisions.
- Adheres to University and unit-level policies and procedures and safeguards University assets.
This list of duties and responsibilities is not intended to be all-inclusive and may be expanded to include other duties or responsibilities as necessary.
Ph.D. required. Master’s or Doctoral degree preferred (in immunology, cancer biology, molecular biology, biochemistry, or genetics, preferred.
Demonstrated track record of productive research experience in oncology or immuno-oncology with at least one peer-reviewed first-author scientific publication, preferred.
Knowledge, Skills and Attitudes:
Knowledge of innate and adaptive immune biology, including myeloid cells, neutrophils, macrophages, CD4+ and CD8+ T lymphocytes, is desired.
Excellent communication and organizational skills
Able to work independently
Have strong analytical skills
Able to think creatively about experimental design
Skill in collecting, organizing, and analyzing data.
Ability to recognize, analyze, and solve a variety of problems.
Ability to exercise sound judgment in making critical decisions.
The University of Miami offers competitive salaries and a comprehensive benefits package including medical, dental, tuition remission and more.
UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.
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Job Status:Full time
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