This position will focus on drug discovery for serotonin G protein-coupled receptors (GPCRs). In collaboration with a major company, we aim to discover novel serotonergic ligands for treatment of depression and other neuropsychiatric disorders. The lab is a highly-creative, fast-paced and dynamic environment capable aimed at publishing in high impact journal in the neurosciences.
- Independently design and execute complex experiments relevant to designated research project.
- Perform high-throughput radioligand and signaling assays in 96-well or 384-well format for a variety of GPCRs.
- Perform molecular biology techniques to make new DNA constructs (PCR, Gibson assembly, restriction digest, DNA preparation, cloning/subcloning, sequence analysis etc).
- Maintain an organized and up-to-date laboratory notebook and computer, adhere to laboratory protocol and existing methodologies, perform data analysis according to laboratory specifications.
- Teach and guide technicians and rotating graduate students to perform various biochemical assays, and mentor them on experimental design and data interpretation.
- Participate in collaborations and communications with principal investigators and fellow scientists where when needed for projects.
- Participate in regular one-on-one and lab meetings with principal investigator and research staff and evaluate/interpret the validity of data, develop methodologies, evaluate lab procedures.
- Interact and participate in departmental meetings, including relevant seminars and journal clubs.
Knowledge – Skills – Abilities
Individual should be highly-motivated and well-organzied, capable of independent work in a laboratory setting with:
- Strong background in signal transduction and/or drug discovery at GPCRs required.
- Extensive experience in molecular biology techniques (preferred).
- Extensive experience with in vitro signaling assays.
- Ability to exhibit common molecular biology techniques such as PCR, transformation, DNA preparation, and analysis of sequences.
- Be highly self-motivated with strong data management and organizational skills, and the ability to think and work independently.
- Strong scientific communication skills and scientific integrity.
- Publication history strongly recommended.
Minimum Required Education: PhD
Minimum Required Experience: Prior experience in biological or chemistry-related field preferred.
Preferred Education: PhD in Chemistry, Biology or Pharmacology
Preferred Experience: Tissue Culture, High-throughput Assays, Experiment Design
Field: Pharmacology and Biochemistry
The Medical College of Wisconsin (MCW) is one of the largest healthcare employers in Wisconsin. We are a distinguished leader and innovator in the education and development of the next generation of physicians, scientists, pharmacists and health professionals; we discover and translate new knowledge in the biomedical and health sciences; we provide cutting-edge, collaborative patient care of the highest quality; and we improve the health of the communities we serve.
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