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Postdoctoral Fellow
Medical College of Wisconsin in Milwaukee, Wisconsin
Date Posted 02/03/2021
Admin-Other Administrative Positions
Employment Type
Application Deadline Open until filled

Position Description:


This position will focus on drug discovery for serotonin G protein-coupled receptors (GPCRs). In collaboration with a major company, we aim to discover novel serotonergic ligands for treatment of depression and other neuropsychiatric disorders. The lab is a highly-creative, fast-paced and dynamic environment capable aimed at publishing in high impact journal in the neurosciences.

Primary Functions                  

  •   Independently design and execute complex experiments   relevant to designated research project.
  •   Perform high-throughput radioligand and signaling assays in   96-well or 384-well format for a variety of GPCRs.
  •   Perform molecular biology techniques to make new DNA constructs (PCR,   Gibson assembly, restriction digest, DNA preparation, cloning/subcloning, sequence   analysis etc).
  •   Maintain an organized and up-to-date laboratory notebook and   computer, adhere to laboratory protocol and existing methodologies, perform   data analysis according to laboratory specifications.

  •   Teach and guide technicians and rotating   graduate students to perform various biochemical assays, and mentor them on   experimental design and data interpretation.
  •   Participate in collaborations   and communications with principal investigators and fellow scientists where   when needed for projects.

  •   Participate in   regular one-on-one and lab meetings with principal investigator and research   staff and evaluate/interpret the validity of data, develop methodologies,   evaluate lab procedures.
  •   Interact and participate in   departmental meetings, including relevant seminars and journal clubs.

Knowledge – Skills – Abilities

Individual should be highly-motivated and well-organzied, capable of independent work in a laboratory setting with:

  • Strong background in signal transduction and/or drug discovery at GPCRs required.
  • Extensive experience in molecular biology techniques (preferred).
  • Extensive experience with in vitro signaling assays.
  • Ability to exhibit common molecular biology techniques such as PCR, transformation, DNA preparation, and analysis of sequences.
  • Be highly self-motivated with strong data management and organizational skills, and the ability to think and work independently.
  • Strong scientific communication skills and scientific integrity. 
  • Publication history strongly recommended.

Preferred Schedule:

Position Requirements:

Minimum Required Education:               PhD

Minimum Required Experience:              Prior experience in biological or chemistry-related field preferred.

Preferred Education:                              PhD in Chemistry, Biology or Pharmacology

Preferred Experience:                            Tissue Culture, High-throughput Assays, Experiment Design

Field:                                                    Pharmacology and Biochemistry

About MCW
The Medical College of Wisconsin (MCW) is one of the largest healthcare employers in Wisconsin. We are a distinguished leader and innovator in the education and development of the next generation of physicians, scientists, pharmacists and health professionals; we discover and translate new knowledge in the biomedical and health sciences; we provide cutting-edge, collaborative patient care of the highest quality; and we improve the health of the communities we serve.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.

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