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COVID-19 Viral Glycoprotein or Small Molecule Inhibitor Charcaterization
National Institutes of Health in Silver Spring, Maryland
 
 
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Date Posted 12/17/2020
Category
Admin-Other Administrative Positions
Employment Type
Application Deadline Open until filled
 
 
 
 
 

The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Silver Spring, Maryland


Position Description:

The Joyce Laboratory, Henry M. Jackson Foundation supporting the Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research have openings for two postdoctoral positions and a Lab Manager position in Structural Biology of Emerging Infectious Diseases:

  • One postdoctoral position involves the structural and biochemical characterization of small molecule inhibitors against Emerging Infectious pathogens including SARS-CoV-2, as part of an integrated drug development pipeline at WRAIR.
  • One postdoctoral position involvesthe structural and biochemical characterization of viral glycoproteins from Emerging Infectious pathogens including SARS-CoV-2 to enable vaccine development, antibody therapeutics and small molecule inhibitors.
  • Responsibilities:

  • Conducts independent research and learns techniques required to conduct the research.
  • Assists in designing, developing, executing, and implementing scientific research and/or products.
  • Develops a thorough understanding of the scientific literature relating to the research topics.
  • Collects and handles samples and keeps detailed inventory and records of experiments by maintaining up to date, clear, and accurate laboratory notebooks.
  • Executes projects related to biochemical and structural characterization of antibodies, vaccine candidates and their complexes.
  • Analyzes experimental data, applying relevant statistical and bioinformatic models.
  • Presents data at scientific meetings and publishes original research in peer-reviewed journals.
  • Assists with training laboratory staff and collaborates with labs within and outside of EIDB.
  • Follows all EIDB and WRAIR safety procedures and completes required training in a timely manner.

  • Qualifications:

    Required Knowledge, Skills and Abilities: 

    Experience in structural biology or related area with significant experience in X-ray protein crystallography or Cryo-EM. Knowledge of appropriate scientific area; ability to analyze and interpret data. Experience and proficiency in protein purification, protein characterization, X-ray crystallography including up-to-date knowledge of relevant programs including CCP4, and Phenix packages. Experience with project planning, implementation, and data analysis. Experience in presenting at scientific meetings and writing manuscripts for scientific journals. Practical knowledge of molecular modelling or structure-based mutagenesis and design is an advantage.

    Minimum Education:

    Doctoral degree in structural biology, molecular biology, immunology, microbiology, biochemistry or related discipline required. 4+ years post-baccalaureate laboratory experience in X-ray crystallography, Electron Microscopy or structural biology.

    Background/Security:

    Must have lived in the U.S. 3 out of the past 5 years; eligible to obtain and maintain a Tier I investigation/ Public Trust and a Common Access Card (CAC).

    Employment with HJF is contingent upon successful completion of a background check, which may include, but is not limited to, contacting your professional references, verification of previous employment, addresses, education, and credentials, a criminal background check, drug screening, and a department of motor vehicle (DMV) check.

    Any qualifications to be considered as equivalents, in lieu of stated minimums, require the prior approval of the Chief Human Resources Officer.


    To Apply:

    Interested candidates should apply at the sites indicated below, or with a cover letter and a current CV directly to Gordon Joyce gjoyce@eidresearch.org .

  • Characterization of small molecule inhibitors against Emerging Infectious pathogens including SARS-CoV-2, as part of an integrated drug development pipeline at WRAIR: https://recruiting.ultipro.com/HEN1006HMJ/JobBoard/3a6861f3-0883-4466-8b7d-35e87635b33d/OpportunityDetail?opportunityId=01d3c013-4b96-4f68-8d58-5ca1b631ba2e
  • Characterization of viral glycoproteins from Emerging Infectious pathogens including SARS-CoV-2 to enable vaccine development, antibody therapeutics and small molecule inhibitors: https://recruiting.ultipro.com/HEN1006HMJ/JobBoard/3a6861f3-0883-4466-8b7d-35e87635b33d/OpportunityDetail?opportunityId=badea1fa-6ab9-4be5-8ddb-57530404a901
  • This post will be available until March 3, 2021 or until filled.

    The NIH is dedicated to building a diverse community in its training and employment programs.


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