This job has Expired
Post-doctoral Associate
Job Description
Full job description
Position Details
Position Information
Recruitment/Posting Title
Post-doctoral Associate
Department
SEBS-Plant Biology
Salary
Commensurate With Experience
Posting Summary
A joint postdoctoral position is available in the laboratories of Dr. Nilgun E. Tumer in the Department of Plant Biology and Dr. Jacques Roberge in the Office of Research at Rutgers University to identify small molecule inhibitors against ricin and Shiga toxin 2 (Stx2).
Shiga toxins are the main virulence factors of Shiga toxin producing E. coli (STEC) that causes food poisoning and ricin is a worldwide problem as a biothreat agent. There is no effective therapy and there is an urgent need to counter disease caused by these toxins. We have used fragment-based drug discovery (FBLD) with surface plasmon resonance using Biacore 8K+ to identify lead compounds that bind to ricin and Shiga toxin 2 (Stx2) and inhibit their activity. The successful candidate will work on optimizing the compounds identified from our recent work using fragment-based methods and structure-based design 1-4. Fragment optimization by medicinal chemistry, as well as docking and binding site analysis by SiteMap, WaterMap and FEP+ will be used to optimize the leads. The affinities will be determined using a fluorescence polarization assay, potency will be analyzed in cell-free and cell-based assays. A virtual screen will be carried out to identify new chemical scaffolds and new binding elements to combine with our current leads. The ideal candidate should have a Ph.D. in medicinal chemistry or a related field and experience in synthetic chemistry, computational docking and screening for drug discovery.
Interested applicants must apply online through ROCS system of Rutgers University
https://jobs.rutgers.edu/postings/223721 and upload CV, research interests, PhD certification, and contact information for at least 4 references.
https://jobs.rutgers.edu/postings/223721 and upload CV, research interests, PhD certification, and contact information for at least 4 references.
Information on Dr. Tumer’s research can be found at:
https://plantbiology.rutgers.edu/faculty/tumer/Nilgun_Tumer.html
https://plantbiology.rutgers.edu/faculty/tumer/Nilgun_Tumer.html
And for Dr. Jacques Roberge can be found at:
https://research.rutgers.edu/people/jacques-y-roberge
1. Rudolph, M. J.; Dutta, A.; Tsymbal, A. M.; McLaughlin, J. E.; Chen, Y.; Davis, S. A.; Theodorous, S. A.; Pierce, M.; Algava, B.; Zhang, X.; Szekely, Z.; Roberge, J. Y.; Li, X. P.; Tumer, N. E., Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin. Bioorg Med Chem 2024, 100, 117614.
2. Rudolph, M. J.; Davis, S. A.; Tumer, N. E.; Li, X. P., Structural basis for the interaction of Shiga toxin 2a with a C-terminal peptide of ribosomal P stalk proteins. J Biol Chem 2020, 295 (46), 15588-15596.
3. Li, X. P.; Harijan, R. K.; Kahn, J. N.; Schramm, V. L.; Tumer, N. E., Small Molecule Inhibitors Targeting the Interaction of Ricin Toxin A Subunit with Ribosomes. ACS Infect Dis 2020, 6 (7), 1894-1905.
4. Li, X. P.; Harijan, R. K.; Cao, B.; Kahn, J. N.; Pierce, M.; Tsymbal, A. M.; Roberge, J. Y.; Augeri, D.; Tumer, N. E., Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design. J Med Chem 2021, 64 (20), 15334-15348.
Position Status
Full Time
Posting Number
24FA0289
Posting Open Date
03/15/2024
Posting Close Date
Qualifications
Minimum Education and Experience
Ph.D. in medicinal chemistry or a related field, and experience in synthetic chemistry, computational docking and screening for drug discovery.
Certifications/Licenses
Ph.D.
Required Knowledge, Skills, and Abilities
Equipment Utilized
Physical Demands and Work Environment
Overview
Statement
Information on Dr. Tumer’s research can be found at: https://plantbiology.rutgers.edu/faculty/tumer/Nilgun_Tumer.html
And for Dr. Jacques Roberge can be found at:
https://research.rutgers.edu/people/jacques-y-roberge
Posting Details
Special Instructions to Applicants
Interested applicants must apply online through ROCS system of Rutgers University
https://jobs.rutgers.edu/postings/223721 and upload CV, research interests, PhD certification, and contact information for at least 4 references.
https://jobs.rutgers.edu/postings/223721 and upload CV, research interests, PhD certification, and contact information for at least 4 references.
Quick Link to Posting
https://jobs.rutgers.edu/postings/223721
Campus
Rutgers University-New Brunswick
Home Location Campus
Cook (RU-New Brunswick)
City
New Brunswick
State
NJ
Location Details
Plant Biology Department, 59 Dudley Road – Foran Hall, New Brunswick, NJ 08901
Pre-employment Screenings
All offers of employment are contingent upon successful completion of all pre-employment screenings.
Immunization Requirements
Under Policy 60.1.35 Immunization Policy for Rutgers Employees and Prospective Employees, Rutgers University requires all prospective employees to provide proof that they are vaccinated against COVID-19 prior to commencement of employment, unless the University has granted the individual a medical or religious exemption. Rutgers University may require certain prospective employees to receive an updated (bivalent) vaccine dose. Under Policy 100.3.1 Immunization Policy for Covered Individuals, if employment will commence during Flu Season, Rutgers University may require certain prospective employees to provide proof that they are vaccinated against Seasonal Influenza for the current Flu Season, unless the University has granted the individual a medical or religious exemption. Additional infection control and safety policies may apply. Prospective employees should speak with their hiring manager to determine which policies apply to the role or position for which they are applying. Failure to provide proof of vaccination for any required vaccines or obtain a medical or religious exemption from the University will result in rescission of a candidate’s offer of employment or disciplinary action up to and including termination.
*Please mention you saw this ad on AcademicJobs.*
