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Conduct collaborative research to examine the neuronal populations and circuity underlying brain control of metabolism and energy homeostasis. This research includes examination of the function and regulation of hindbrain and hypothalamic neuronal populations and their role in feeding behavior and gastric function. Specific duties include ex vivo functional analysis of neuronal populations in mouse and rat models in various brain regions, using ex vivo slice patch clamp recordings in voltage and current clamp mode, and measuring spontaneous and electrically or optically evoked synaptic currents; conducting ex vivo calcium imaging on confocal microscope to monitor neuronal activity across large neuronal populations; developing calcium imaging methodology using an epifluorescence microscopy system; perform stereotaxic injection of viruses for expression of proteins and fiber implantation; performing in vivo measurements of neuronal activity using electrical or fluorescence-based measurements, such as fiber photometry and optogenetic stimulation; conducting whole animal physiologic measurements, such as body weight, food intake, blood glucose, activity, place preference, and gastric function; overseeing maintenance of lab equipment, including slice electrophysiology equipment, vibratome, fiber photometry system, calcium imaging systems, and optogenetic equipment; and managing animal colony. Additional responsibilities include: design and execution of experiments, data analysis, interpretation and presentation, and manuscript preparation; technique development, including the set-up of in vivo calcium imaging of hindbrain and hypothalamic regions using microendoscopy with GRIN lenses; research on new reagents and technology for advancement of scientific goals; grant preparation; training and mentoring new lab personnel; and pursuit of independent projects to contribute to the overall goal of understanding the neural control of metabolism and gut-brain communication.
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Requires PhD degree in Neuroscience, Neurobiology, Physiology, or closely related field + 1 year of postdoctoral experience performing electrophysiology research focused on gut-brain circuitry; using stereotaxic method to inject virus into in vivo animal model; preparing acute brain slices; using patch clamp and evoked current recordings to identify synaptic and circuitry physiology; and using Matlab to program protocols for patch clamp.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
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The University of Michigan is an equal opportunity/affirmative action employer.