POSTDOCTORAL SCIENTIST - MALARIA PARASITE EVOLUTIONARY GENETICS

TheRole:
Tim Anderson's laboratory at the Texas Biomedical Research Institute is searching for an enthusiastic postdoctoral researcher to work on adaptive evolution in the malaria parasite, Plasmodium falciparum. These parasites can be maintainedin the laboratory, so are amenable to experimental and functional analyses.Genetic crosses can be conducted allowing linkage analysis of parasite traits,while CRISPR based gene editing and nanopore sequencing is established in ourlaboratory. Malaria parasites are thetarget of aggressive ongoing control programs in endemic areas, so are idealorganisms for studying ongoing selective events in nature. We have long-termcollaborations with researchers in SE Asia, and collections of parasitesspanning two decades. The successful candidate will work with existing genomicdatasets, and develop new projects involving analyses of field collectedparasites, experimental laboratory populations, and genetic crosses. This is anexcellent opportunity for someone who would like to work on the evolutionarybiology of an important human pathogen.

Thesuccessful applicant will join a vigorous infectious disease program at Texas Biomed (including work on malaria, schistosomiasis, Ebola, influenza,coronavirus, HIV, and TB). Texas Biomed provides a stimulating environment withwork on population genomics, quantitative genetics, and has outstandingcomputational and wet lab facilities. San Antonio is a vibrant, rapidly growingcity with an interactive research community, and affordable housing.

OurIdeal Candidate:
A highlymotivated individual with a Ph.D. in evolutionary biology, genetics, molecularbiology, or a related discipline. Strong bioinformatic skills ideal. Ability toconduct/supervise laboratory research is an advantage. No experience of malariaparasite research necessary.

WhoWe Are:
Texas Biomedical Research Institute is one of the world's leading independent biomedical research institutions dedicated to advancing global human health through innovative biomedical research. Texas Biomed aims to unravel the mysteries of infectious diseasesthrough innovative thinking, creative problem solving and cutting-edgetechnologies. The Southwest NationalPrimate Research Center (SNPRC) provides broad services in primate research. Weare one of seven National Primate Research Centers (NPRCs) with specializedtechnologies, capabilities and primate resources, many of which are unique tothe SNPRC.

WhatWe Can Offer You:
• Competitivepay
• 7%Employer-Funded retirement contribution starting day one
• Fullinsurance benefits
• Holidays,PTO and a paid week off in the last week of December
• Hybrid workenvironment (work partially from home and on campus)

RelevantPublications:
• Phyo, A.P et al. Emergence of artemisinin-resistant malaria on the western border of Thailand: A longitudinal study. Lancet 2012; 379:960-1966. PMC3525980;
• Cheeseman, I.H., et al. A major genome region underlying artemisinin resistance in malaria. Science 2012; 336:79-82. PMC3355473;
• Cheeseman IH et al.Population Structure Shapes Copy Number Variation in Malaria Parasites.Mol Biol Evol.2016 Mar;33(3):603-20. PMCID: PMC4760083;
• Anderson TJ, et al. Population parameters underlying an ongoing soft sweep in Southeast Asian malaria parasites. Mol Biol Evol. 2017 Jan; 34(1): 131-144. PMCID: PMC5216669;
• Li X, et al. Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle. PLoS Genet. 2019;15(10):e1008453. PMCID: PMC6821138;
Amambua-Ngwa A, et al. Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1. Nat Micro 2023; 8(7):1213-26. PMCID: PMC10322710.

Publication List: https://www.ncbi.nlm.nih.gov/sites/myncbi/tim.anderson.1/bibliography/40734139/public/?sort=date&direction=descending

Lab Website: https://texasbiomedical.theopenscholar.com/anderson-lab/

** All newhires must present proof of an up to date COVID-19 immunization record toinclude booster(s) if eligible.

Texas Biomedical Research Institute provides equal employment opportunities for all qualified employees and applicants without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status.

Apply Here: https://www.click2apply.net/XREmqgSV4BydqIZLkcdlPJ

PI230259840