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Senior Scientist – Oncology Biomarker Discovery
Amgen Inc - SSF in South San Francisco, California
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Date Posted 06/25/2020
Employment Type Fulltime
Application Deadline Open until filled

Career Category


Job Description

Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions. To underpin our commitment to serve patients, Amgen is developing a Biomarker-Discovery group to support therapeutic programs.

The Department of Inflammation and Oncology Research is seeking a highly motivated Senior Scientist to study disease mechanisms and develop preclinical biomarker and diagnostic strategies to support our innovative oncology pipelines. In this role you will work cross-functionally and interact closely with both the Discovery Research and Clinical Biomarker groups, as well as with other functions including Therapeutic Discovery, Human Genetics, Computational Biology, and Translational Medicine.

The successful candidate will independently lead and perform cutting edge research to investigate the molecular and cellular heterogeneity of human cancers with unmet medical needs. You are expected to lead the program to stratify patients based on disease driving mechanisms, develop preclinical biomarker and diagnostic strategies and generate supporting data. The successful candidate will also characterize the mechanisms of response and resistance to our therapeutic assets and inform novel research activities.

Position Responsibilities

Develop deep disease area expertise for key oncology indications

Investigate disease biology and heterogeneity using human genetics, single cell transcriptomics, proteomics, cellular assays and/or preclinical animal models of human cancer

Discover and prioritize disease stratification and target engagement biomarker candidates for multiple pipeline projects

Generate and transition key pharmacodynamic and patient stratification biomarker discovery data in support of clinical biomarker assay development

Develop, implement, and execute a therapeutic biomarker discovery strategy across multiple programs

Support translational biomarker activities for therapeutic assets including investigator meetings /ad boards and investigator-sponsored studies for correlative biomarker research together with the Clinical Biomarker lead

Publish and present at national/international conferences

Basic Qualifications

Doctorate degree and 2 years of scientific experience


Master's degree and 5 years of scientific experience


Bachelor's degree and 7 years of scientific experience

Preferred Qualifications

Ph.D or MD, with postdoctoral trainings and research experience in the field of cancer immunology, immunology, human genetics, or molecular biology

Technical expertise in one or more of the following areas: Multi-color flow cytometry, complex cell-based functional assays, genetic manipulation of cell lines and/or primary cells, cell signaling/biochemistry, in vivo mouse models of disease, and bioinformatics

Demonstrated track record of independent critical thinking and scientific achievement in research, exemplified by a strong publication record and/or significant contributions to a therapeutic development or biomarker discovery program

Demonstrated experience in leading teams in a matrixed-environment and consistently delivering results

Experience with implementing multiple technology platforms would be a plus

Strong verbal and written communication skills

Knowledgeable, highly motivated, creative, and collaborative


At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our “people-first” philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.

Consistent with our core leadership value of “Develops the Best Team,” we are seeking leaders that prioritize the development of talent. As a manager, your first priority and primary role is to accelerate the performance and development of your team. We expect managers to exemplify strong leadership and champion self-awareness and career development. Ways that you will display your leadership acumen in this role include:

  • Mentoring, coaching, and developing staff to build highly-skilled, diverse, and inclusive teams
  • Fostering a positive and respectful work environment that encourages staff retention and motivates individuals to work toward common goals and priorities
  • Ensuring that staff understand how their efforts and contributions make a meaningful impact to the business
  • Growing core skills and capabilities among staff, particularly in learning agility, problem solving, strategic and creative thinking, flexibility, resilience, effective communication, prioritization, delivery of results, and continuous improvement
  • Making accurate evaluations of your team's skills and competencies and providing timely and respectful feedback, including direct delivery of difficult messages
  • Developing an understanding of your team's career objectives and serve as a thought-partner in their career development plans


A Fortune 150 company operating in nearly 100 countries around the world, we invest in highly skilled, dedicated and collaborative individuals who are ready to contribute to our mission in meaningful ways and make a difference in the lives of our patients. That’s why, as a member of our cross functional, cross discipline team, we provide you with valuable opportunities to broaden your experience and maximize your potential. Focused on the industry’s most compelling scientific discoveries and housed within industry leading facilities within the heart of the world’s leading biotechnology hub, our colleagues are growing our pipeline through groundbreaking innovations. We believe in rewarding those who do rewarding work and are committed to providing careers that can help turn the tide of serious, life interrupting illnesses.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.


As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

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