The Oncology & Immuno-Oncology team at Regeneron is seeking a highly motivated Postdoc to lead research into the mechanisms of clonal hematopoiesis of indeterminate potential (CHIP) and the transition from benign carrier state to overt malignancy. You will work closely with peers across oncology, hematology, aging and the Regeneron Genetics Center while pursuing an independent research project. The ideal candidate will be a creative thinker with a background in blood cancer, hematology, or immunology research.

CHIP is a condition where hematopoietic stem cells acquire leukemia-associated mutations and begin to clonally expand relative to their peers. While CHIP is not a cancer, CHIP carriers are at elevated risk for future blood cancers and numerous other diseases. Our team at Regeneron has been working to understand what mechanisms underlie this transition from benign carrier state to cancer, and whether there are opportunities to intercept disease in the early, pre-malignant stage. If you would like to play a key role in shaping our understanding of CHIP and other pre-malignant clonal cell expansion disorders, apply now!

In this role a typical day might include:

• Independently developing and performing bioassays to screen and characterize key signaling molecules and how they participate in normal and malignant hematopoiesis.

• Animal experimentation, including dissection of tumors/major immune organs for immune cell isolation and subsequent analysis.

• Designing sophisticated flow cytometry (FACS) panels and performing FACS analysis on immune cells isolated from tumors and tissues.

• Independently crafting, planning, and performing complex anti-tumor efficacy studies in mice.

• Maintaining tumor cell lines and engineering cell lines using various methods including lipofection, nucleofection, and viral transduction.

• Analyzing data using biological and statistical software such as Flowjo, Prism, Excel, etc.

• Collaborating closely with cross-functional teams across the company.

• Compiling results across experiments and programs and presenting them to multi-disciplinary teams, including translational teams, and senior management.

• Participating in post-doctoral program activities (e.g., meetings and research conferences)

• Continuously following the current relevant literature, attending scientific meetings, and maintaining expertise in hematology and hematological malignancies.

This role may be for you if you:

• Are a creative thinker with a track record of productivity.

• Possess a strong desire to contribute to cutting-edge research centered on understanding the molecular underpinnings of how clonally expanded blood cells cause disease.

• Have outstanding scientific skills, including critical and analytical thinking.

• Have strong communication and presentation skills.

• Enjoy actively participating and effectively collaborating in cross-functional projects that involve multiple teams.

To be considered for this role, you must have a Ph.D. in oncology, immunology, hematology, or cell biology. We are looking for someone with hands-on experience in techniques such as flow cytometry, cell culture, and mouse experimentation. Expertise in hematopoietic stem cell biology and/or immunology is highly desired. You will have the opportunity to lead a research project in a fast-paced and results-driven environment.

Please note, the specific starting salary for this role is $86,000.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$69,500.00 - $113,500.00