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The Sylvester Comprehensive Cancer Center and the Department of Surgery have an exciting opportunity for a Post-Doctoral Associate position in breast cancer research. The candidate will perform scientific research under the supervision of Dr. Karoline Briegel to study the molecular mechanisms underlying breast cancer heterogeneity, metastatic progression, and treatment resistance, with a focus on novel WNT transcriptional/epigenetic mechanisms controlling epithelial lineage plasticity and cancer stem cell formation/maintenance. The individual will take a multidisciplinary approach, including protein-protein interaction studies, next generation sequencing, stem cell assays, and spatial multiplex analysis of the tumor microenvironment, in combination with patient-derived organoid and mouse in vivo models of breast cancer. 

CORE JOB FUNCTIONS                                                                                              

• Conducts independent research and experiments on specific areas of the study as assigned.

• Prepares research reports and manuscripts for publishing.

• Investigates the feasibility of applying a wide variety of scientific principles and theories.

• Maintains substantial knowledge of state-of-the-art principles and theories.

• Develops advanced analytical models and systems and provides solutions and analyses to support strategic and tactical decisions.

• Adheres to University and unit-level policies and procedures and safeguards University assets.

This list of duties and responsibilities is not intended to be all-inclusive and may be expanded to include other duties or responsibilities as necessary.

CORE QUALIFICATIONS                                                                                            

• Ph.D. required, in Biochemistry, Molecular Biology, Cell Biology, Immunology, Cancer Biology, or other life sciences.

• No more than 0-1 years of prior postdoctoral experience.

Experience, Knowledge, Skills:

• Prior experience in protein-protein interaction studies, single cell analysis, imaging mass cytometry, FACS analysis, organoid cell culture, stem cell research, innate immunity, autophagy, and/or epigenetic/transcription factor analysis preferred.

• Excellent communication skills in English (both verbal and written) required.

• Minimum of one first-author published manuscript in relevant field.

Department Specific Functions

Applicant must be independent, self-motivated, and goal oriented, and possess a demonstrated strong interest and skill set in the exploration of molecular mechanisms. The candidate will have access to state-of-the art proteomic, transcriptomic, genomic, and spatial multiplex analysis platforms (e.g., single cell RNA-Seq, Hyperion imaging cytometry) and work with breast cancer patient-derived models, human cell lines, and genetic mouse models. A background in breast cancer research, mammary gland biology, transcription factor biology, and or tumor immunology is desirable.

Duties include but are not limited to conceiving and executing experiments on several aspects of the research project, data analysis and presentation, lab organization, presenting seminars and other forms of research communication.

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The University of Miami offers competitive salaries and a comprehensive benefits package including medical, dental, tuition remission and more.

UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

Patient safety is a top priority. As a result, during the Influenza ("the flu") season (September through April), the University Of Miami Miller School Of Medicine requires all employees who provide ongoing services to patients, work in a location (all Hospitals and clinics) where patient care is provided, or work in patient care or clinical care areas, to have an annual influenza vaccination. Failure to meet this requirement will result in rescinding or termination of employment.

The University of Miami is an Equal Opportunity Employer - Females/Minorities/Protected Veterans/Individuals with Disabilities are encouraged to apply. Applicants and employees are protected from discrimination based on certain categories protected by Federal law. Click here for additional information.

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