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Senior Scientist/Oncology Bioscience – Cell Death
AstraZeneca in Waltham, Massachusetts
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Date Posted 07/12/2019
Science-Cell Biology
Employment Type Fulltime
Application Deadline Open until filled

Senior Scientist/Oncology Bioscience – Cell Death

Waltham, MA

At AstraZeneca, we work together across global boundaries to discover, develop, and deliver innovative and meaningful medicines and other healthcare solutions that enrich the lives of patients as well as their families and communities. In AstraZeneca Oncology, our vision is redefining our solutions to cancer and restoring patients' lives.

We are seeking a highly motivated and experienced scientist with a strong background in molecular and cellular biology to join the Oncology Bioscience group in Boston as a lab-based Senior Scientist. You will be a key member of a dynamic and collaborative cross-functional Cell Death Team. Your primary responsibility will be to develop and run cell-based assays to support preclinical drug development of projects from target validation up through phase 2 clinical trials. These efforts will ultimately lead to the identification of drug candidates and the generation of compelling preclinical data packages to progress promising drug discovery projects towards clinical development.

Key responsibilities

  • Routine delivery of medium- to high-throughput in vitro compound screening assays to support medicinal chemistry within projects

  • Independent development and implementation of various cell-based assays to evaluate mechanism of action, biological effect, anti-tumor activity, target engagement requirements, patient selection, and combination/resistance mechanisms for projects within the oncology portfolio

  • Analysis, interpretation and presentation of data and its implications for the project(s)

  • Maintenance of laboratory records, protocols, summaries, and reports

  • Awareness and reporting of current developments in the literature related to the project


Essential Requirements

  • BS/MS with 5+ years of industry experience in biochemistry, molecular/cellular biology or equivalent fields. A PhD is not required.

  • Experience in drug discovery, especially within oncology

  • Strong expertise in mammalian cell culture, including transfections and stable clone generation

  • Prior laboratory experience with molecular and cell-based assays, including but not limited to apoptosis assays, proliferation assays, flow cytometry, ELISA, western blotting, RT-qPCR, and reporter assays

  • Familiarity with independently designing, executing, and analyzing in vitro combination experiments

  • Mouse handling and dosing experience is a plus but not required

  • Demonstrated proficiency in data processing, preferably with GraphPad Prism or Spotfire, and data management

  • Excellent problem-solving skills with a delivery focus

  • Ability to work in a matrixed, team-oriented environment

  • Strong interpersonal and communication skills


Next Steps – Apply today!


AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

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