Position Summary

As a Postdoctoral Research Associate, you will be involved in the development of novel molecules in addition to clinical translation of lead agents for biomedical imaging. Specifically relevant to current position, you will design and develop small organic molecules amenable to incorporation with carbon-11 or fluorine-18 for use in PET neuroimaging. You will also be involved in translating new molecular imaging probes into human research. You will be a valuable member of the team and get experience in all stages of PET radiotracer development from PET radiotracer design to preclinical and clinical evaluation to data interpretation. You will get experience working with both academic and industry collaborators. You will also get experience communicating with regulatory authorities such as the FDA.

Information on being a postdoc at Washington University in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/ .

Primary Duties & Responsibilities

• Develop new methods to radiolabel small molecules with carbon-11 or fluorine-18.
• Adapt radiolabeling of small molecules on automated synthesis units (e.g., Tracerlab FX2N, FXPro, FXM).
• Perform preclinical or cGMP compliant production of radiotracers using automated radiosynthesis platforms for preclinical and clinical use.
• Develop chromatographic methods to analyze, characterize and purify radiolabeled compounds (HPLC, TLC) and analyze produced radiotracers.
• Develop formulations suitable for use in preclinical and clinical studies.
• Analyze blood samples for radioactive metabolites.
• Maintain clear and accurate records.
• Compose and follow standard operating procedures (SOPs).
• Analyze and  summarize data for publications.
• Assist in writing Chemistry, Manufacturing and Controls (CMC) documents for regulatory submissions (RDRC and/or IND).
• Assist in establishing both new and maintain current collaborations with both internal and external academic and/or industrial collaborators.
• Assist in grant application preparations.

Required Qualifications

Ph.D. in chemistry or related field is required.

Preferred Qualifications

• Experience in radiochemistry is highly preferred, especially with C11 or F18.
• Experience in organic and analytical chemistry is highly preferred.
• Experience in medicinal chemistry.
• Experience with organofluorine chemistry is advantageous.
• Ability to work both independently and as part of a team.
• Strong communication skills.
• Ability to prioritize, multitask, and troubleshoot problems.

Working Conditions

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range

Base pay is commensurate with experience.

Accommodation

If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu  or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.

Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.

EEO/AA Statement
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.

Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.