The Center for Cancer Research (CCR), in the National Cancer Institute (NCI) invites applications for a Post-doctoral position in the Laboratory of Receptor Biology and Gene Expression, located in Bethesda, Maryland. The candidate will be trained under the leadership of Shalini Oberdoerffer, Ph.D. The Oberdoerffer group explores how RNA epigenetics dynamically regulates post-transcriptional mRNA fate. Building on recent observations that a single epitranscriptomic modification promotes or represses mRNA translation in a position-dependent manner (Arango et al., Cell , 2018; Arango et al., Molecular Cell , 2022), current directions encompass investigating the enzymatic regulation of mRNA modifications in normal development and disease, and examining whether their distinctive influences on translation can be harnessed for therapeutic purposes. The laboratory aims to recruit  a candidate with expertise in RNA biology to explore the molecular mechanisms by which mRNA modifications modulate translation and evade immune detection towards the development of novel mRNA-based cancer therapeutics. Anticipated methodologies include mRNA synthesis and delivery, RNA-sequencing, mass spectrometry, flow cytometry and RNA FISH.

For more information, see: https://ccr.cancer.gov/Laboratory-of-Receptor-Biology-and-Gene-Expression/shalini-oberdoerffer .

The candidate will join an integrated team of bench and computational scientists with common research interests. While candidates with a wide range of expertise will be considered, applicants with a background in nucleic acid modifications, cell biology and immunology are especially encouraged to apply. Applicants must possess a Ph.D. or equivalent and have no more than two years of post-doctoral experience. Successful applicants should have a strong background in gene regulation and RNA biology.

The Center for Cancer Research (CCR) is the intramural research component of the NCI. CCR’s enabling infrastructure facilitates clinical studies at the NIH Clinical Center, provides extensive opportunities for collaboration, and allows scientists and clinicians to undertake high-risk, high-impact laboratory and clinically based investigations. Investigators are supported by a wide array of intellectual, technological and research resources including, animal facilities and dedicated, high-quality technology cores in areas such as imaging/microscopy, chemistry/purification, mass spectrometry, flow cytometry, genomics/DNA sequencing, transgenics and knockout mice, arrays/molecular profiling, and human genetics/bioinformatics.  For an overview of CCR, please visit http://ccr.cancer.gov/ .

Interested individuals should send a curriculum vitae and bibliography, a brief summary of research interests and accomplishments, scientific experience, and the names and addresses of three references to: Dr. Shalini Oberdoerffer, Senior Investigator, LRBGE, National Cancer Institute, E-mail: shalini.oberdoerffer@nih.gov.