Wayne State University is searching for an experienced Post-Doctoral Research Fellow – Hyeong-Reh Kim Laboratory at its Detroit campus location.

Wayne State is a premier, public, urban research university located in the heart of Detroit, Michigan where students from all backgrounds are offered a rich, high-quality education. Our deep-rooted commitment to excellence, collaboration, integrity, diversity and inclusion creates exceptional educational opportunities which prepare students for success in a global society.

Perform scientific techniques or research protocols.  Assist the Principal Investigator in designing and performing protocols. Design and perform experiments. Collect and log research data.  Participate in implementing research objectives, ensuring compliance with all legal, regulatory and protocol guidelines.  Assist other lab members with experiments as required.  May mentor research assistants and students.

With the assistance of the mentor, find and write research grants with the goal of obtaining additional research grant funding. Responsibilities may also include coordinating correspondence with applicants and grantees, acknowledging receipts of proposals, and maintaining a system to track proposals. 

Evaluate and perform preliminary analysis of the data using graphs, charts or tables to highlight the key points of the research results collected in accordance with the research protocols as stipulated.

Prepare and present presentations regarding research project results for professional, scientific and academic conferences.  Summarize and organize data results for submittal to academic and scholarly, peer-reviewed journals.  Write scientific manuscripts and other documents for publication. Fact-check, proofread, and edit research documents to ensure accuracy.

Maintain the laboratory work areas including routine maintenance on laboratory equipment as required.  Order and organize required research supplies and records.  Maintain cleanliness and organization of work station.

Perform other related duties as assigned.

Unique duties:

We are seeking a creative and motivated Postdoctoral Research Fellow to join our collaborative team. Are you a creative and hardworking individual who wants to do research in an interdisciplinary and fun laboratory setting? The Kim Lab at Wayne State University School of Medicine studies clinically relevant questions in cancer biology using tools from the complementary fields of molecular biology, cell biology, biochemistry and mouse modelling. In particular, our cancer biology work focuses largely on unveiling the molecular and cellular mechanisms underlying human cancer progression and developing better therapeutic strategies. Our laboratory has investigated signaling networks regulated by growth factors, extracellular proteinases, oncogenes and tumor suppressors, critical for tumor progression and therapeutic responses for more than 2 decades. Our research group interacts closely with cancer biologists, clinicians, computational biologists, biochemists and biostatisticians/bioinformaticians. Current projects focus on understanding genetic alterations in prostate and breast cancer cells for their ability to interact with the bone microenvironments necessary for intraosseous tumor growth. Recently, we identified a novel tumor suppressor that regulate lipid biology, critical for the regulation of tumor cell dormancy in the bone microenvironment. Current projects also include our long-standing research questions on PDGF ligand-specific signaling programs critical for epithelial-stromal interactions. Our lab also focuses on the interactions of signaling networks with tumor metabolism and programmed cell death pathways. Our novel findings demonstrated that synthetic small molecules targeting tumor cell-specific, lipid metabolic pathways and autophagy induce ferroptotic or apoptotic cell death and improve the effectiveness of radiotherapy in therapy-resistant cancer cells. Using novel mechanism-based degradation of oncoproteins via the autophagy pathway, we aim to investigate the underlying molecular pathways and validate new therapeutic targets in treatment-resistant cancers. Specific responsibilities include: · Designing and executing in vitro and in vivo experiments · Conducting data analysis and interpreting results · Maintaining accurate records, writing reports, and preparing and giving presentations · Contributing to the overall laboratory safety, organization, and productivity

Education - Doctorate degree
Requires advanced knowledge in a field of science or learning, predominantly intellectual in character.
This knowledge is acquired by a prolonged course of specialized intellectual instruction.  
Experience - Intermediate (3 to 4 years job-related experience)
Job related experience can include doctorate training.  Experience performing basic research techniques,
preferred.  Must have distinguished themselves in research.  Prior recipient of funding for research based on individual achievements.

Knowledge, Skills and Abilities: Ability to work independently. Ability to secure grants and funding for research.  Ability to collect, analyze, summarize and interpret research findings in reports and communicate results to the field. Knowledge of and experience with current scientific integrity principles. Excellent time management and organization skills.
Excellent interpersonal skills and demonstrated ability to work with others in a collaborative environment.  Microsoft office software skills.

Preferred qualifications:

Ph.D. in molecular biology, cancer biology, genetics, biochemistry or equivalent. · Must have earned Ph.D. from US institute within 2 years or from foreign institute within 1 year. · Enthusiastic team player, and self-motivated individual · Experience with cell culture and experience (or interest) in mouse disease modeling · Excellent English written and oral communication

H06 - School of Medicine

H0612 - Pathology

• Regular Employee
• Job type: Full Time
• Job category: Research

• Compensation type: Annual Salary
• Hourly rate:
• Salary minimum:
• Salary hire maximum:

Typical work environment may include a laboratory and/or office environment. May require working non-standard business hours including evenings and weekends. May be required to travel to scientific conferences. About Wayne State University: Wayne State University is one of the nation's pre-eminent public research universities in an urban setting and Karmanos Cancer Center is one of 51 National Cancer Institute-designated comprehensive cancer treatment and research centers in the United States. Through our multidisciplinary approach to research and education, and ongoing collaboration with government, industry and other institutions including our University Research Corridor partners – the University of Michigan and Michigan State University – Wayne State University - and our research and technology park, TechTown, seek to expand knowledge, enhance economic growth and improve the quality of life in the city of Detroit, state of Michigan and throughout the world. Through our dedication and leadership, Wayne State University is a nationally recognized center of excellence in research. Our faculty lead the nation in many key research areas and their groundbreaking discoveries make a difference in the everyday lives of others around the corner and around the world, and we strive to continue making an impact by our groundbreaking research. Wayne State University and the Karmanos Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

• Number of openings: 1
• Reposted position: No
• Reposted reason: None (New Requisition)
• Prior posting/requisition number:

University policy requires certain persons who are offered employment to undergo a background check, including a criminal history check, before starting work. If you are offered employment, the university will inform you if a background check is required.

Wayne State University provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. The university encourages applications from women, people of color and other underrepresented people. Wayne State is an affirmative action/equal opportunity employer.