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At Exact Sciences, we're helpingchange how the world prevents, detects and guides treatment for cancer. We give patients and clinicians the clarity needed to make confident decisions when they matter most. Join our team to find a purpose-driven career, an inclusive culture, and robust benefits to support your life while you're working to help others.

Position Overview

The Principal Statistical Programmer applies strong statistical and computational skills to participate in the discovery, development, validation, and post-marketing support of genomic biomarker assays that help cancer patients and their physicians make better treatment decisions. As a member of the clinical biostatistics team, demonstrating prowess in handling complexities with finesse, leveraging advanced programming techniques in SAS and/or R, this role adeptly generates highly intricate analysis datasets, tables, listings, and graphs. Additionally, the Principal Statistical Programmer efficiently conducts ad-hoc analyses, showcasing a capacity for insightful and prompt exploration of data for enhanced decision-making. The Principal Statistical Programmer will create highly complex and innovative data visualizations and generate dashboards using creative techniques in either SAS, R, or Power BI per study needs. In addition, this role will collaborate closely with clinical biostatistics, clinical data operations, clinical development, clinical operations, medical communications, and medical affairs to provide expertise in the generation of statistical analyses and reports.

Essential Duties

Include, but are not limited to, the following:

• Lead projects with higher level of complexity/challenges and difficulties. Lead efforts to resolve complex statistical programming issues or problems.
• Spearhead the development of highly complex analysis datasets with meticulous attention to detail, adhering to standardized formats and defined study specifications.
• Able to gather inputs effectively and develop/update analysis dataset specifications for studies with analysis of any complexity per statistician's input and study requirements requiring little to no rework.
• Demonstrates exceptional proficiency in adeptly managing time constraints amidst the demands of multiple intricate projects simultaneously. Ability to adapt swiftly to changes in timelines or priorities by strategically reorganizing the daily workload.
• Utilize business Intelligence tools, such as Tableau or SAS Stored process, to create insightful and highly complex automated study specific reports of clinical data.
• Able to plan efficiently and proactively inform study team of the status of deliverables and significant data issues, including planned resolutions.
• Meticulously review project documentation such as Statistical Analysis Plan, mock shells, programming specifications, annotated CRFs, and code lists, EDC from programming perspective. Provide insightful feedback to the appropriate study team members which reflects forethought and reduces inefficiencies in programming activities.
• Contribute technical expertise to the development of programming tools and highly complex macros for standardization and efficiency.
• Swiftly identify and resolve highly intricate programming errors with precision and efficiency.
• Provide guidance and mentoring to peer and junior-level programmers.
• Review and validate highly complex and critical regulatory submission programming documents, datasets, tables, listings, and graphs.
• Ensure compliance and adherence to the established data and programming standards.
• Ensure accurate and timely completion of the statistical programming activities for assigned projects; including, but not limited to, exploratory and formal data analyses for final study reports, abstracts, posters, manuscripts, and ad-hoc projects, including verification and documentation of results of any complexity.
• Perform highly complex data analysis by employing advanced techniques in SAS and/or R programming language for the summary and interpretation of medical and clinical data.
• Participate in the review of complex analysis plans and development of programming requirements, as needed.
• Directly support study biostatistician, requiring minimal to no guidance.
• Actively maintain knowledge and understanding of current team, department, and corporate goals and priorities to ensure effective time management and focus. Assist in developing department and functional team goals.
• Interact cross-functionally with biostatisticians and other members of the clinical team to perform ad-hoc analysis and generate data-centric and highly complex reports per team and study requirements.
• Ability to be highly effective and pro-active in a fast-paced and rapid growth environment.
• Apply strong verbal, writing, and presentation skills.
• Ability to communicate professionally and effectively with other functions.
• Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork.
• Support and comply with the company's Quality Management System policies and procedures.
• Maintain regular and reliable attendance.
• Ability to act with an inclusion mindset and model these behaviors for the organization.
• Ability to work on a mobile device, tablet, or in front of a computer screen and/or perform typing for approximately 90% of a typical working day.
• Ability to travel 10% of working time away from work location, may include overnight/weekend travel.

Minimum Qualifications

• Bachelor's degree in computational or Biological Sciences, or field as outlined in the essential duties.
• 8+ years of relevant experience in academia, pharmaceutical, or medical device industry with Master's or 10+ years with Bachelor's in relevant field.
• Demonstrated ability to support highly complex statistical programming projects of clinical data within a fast-paced environment.
• Demonstrated working knowledge of complex statistical theory and advanced statistical programming techniques and procedures; including, but not limited to, SAS.
• Demonstrated working knowledge of a wide application of advanced technical principles, theories, concepts, and techniques.
• Demonstrated ability to perform the essential Duties of the position with or without accommodation.
• Authorization to work in the United States without sponsorship.

Preferred Qualifications

• Master's degree in computational or Biological Sciences, or field as outlined in the essential duties.
• Experience working in an FDA regulated environment.
• Professional working knowledge in multiple therapeutic areas. Oncology, and genomics preferred.
• Previous Biostatistician experience.

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Salary Range:

Exact Sciences is proud to offer an employee experience that includes paid time off (including days for vacation, holidays, volunteering, and personal time), paid leave for parents and caregivers, a retirement savings plan, wellness support, and health benefits including medical, prescription drug, dental, and vision coverage. Learn more about our .

Our success relies on the experiences and perspectives of a diverse team, and Exact Sciences fosters a culture where all employees can develop personally and professionally with a sense of respect and belonging. If you require an accommodation, email We'll work with you to meet your accessibility needs.

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We are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to age, color, creed, disability, gender identity, national origin, protected veteran status, race, religion, sex, sexual orientation, and any other status protected by applicable local, state, or federal law. Any applicant or employee may request to view applicable portions of the company's affirmative action program.

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