Job Summary:

This full-time faculty position will work at ClinImmune Cell & Gene Therapy which is within the Division of Allergy and Clinical Immunology.  ClinImmune provides stem cell banking, stem cell processing, clinical HLA testing for human stem cell and organ transplants, plays a key role in clinical trials conducted at UCH and has two FDA licensed hematopoietic stem cell products used for treating >100 patients per year.  It also holds an FDA IND for use of umbilical cord mesenchymal stem cells in the treatment of diabetic foot ulcers, and a patent for HLA gene editing for the treatment of rheumatoid arthritis.  This position is responsible for providing research and clinical support to ClinImmune in the areas of training, mentoring, assay development, procedure development, the design and implementation of research experiments, and clinical laboratory activities associated with transplant operations.

Key Responsibilities:

The duties and responsibilities of the position include, but are not limited to:

Histocompatibility (HLA) Laboratory

• Specifically conduct research on ClinImmune’s HLA Gene Editing for the treatment of various autoimmune diseases including, but not limited to, Type 1 Diabetes and Multiple Sclerosis. 

Research

• Data collection, processing, and analysis for projects.
• Plan and design research experiments; establishing priorities and recommending schedules, timetables and costs.
• Present research findings to internal and external audiences.
• Operate specialized scientific equipment.
• Perform statistical analyses, including selecting the appropriate analysis procedure, setting up data for analysis, judging validity and reliability of data, designing and programs to perform analyses, and producing written reports on the results of the analyses.
• Effectively use available technology to facilitate the success of the project.
• Write, edit, and submit for grant applications.
• Write, edit, and submit peer reviewed technical publications.
• Design workflow and validations/verifications plans for process development.
• Create validations and verifications associated with process development.
• Planning and managing progress of process development.
• Development of SOPs for process development activities to meet regulations.
• Initiate and monitor training and competency of staff performing process development activities to meet regulations.
• Apply research laboratory experience such as aseptic cell culture, molecular and cell biology assays, and flow cytometry in the development of processes, procedures, and documentation to take research through IND clinical trial phases.
• Manage the laboratory by ordering supplies, taking inventory and ensuring laboratory staff are following lab protocols and guidelines.

Instruction

• Provide training/mentoring to incoming graduate assistants, technicians, researchers, and rotating postdoctoral fellows. 

Work Location:

Onsite - this role is expected to work onsite and is located in Aurora, CO.

Why Join Us:

As an academic based biotechnology company, ClinImmune Cell & Gene Therapy is committed to providing the highest quality service and support to clinical customers and researchers locally and abroad.  Our prime location at the University of Colorado Anschutz Medical Campus allows for collaboration with world-renowned clinicians and scientists.  ClinImmune Cell & Gene Therapy is an academic and clinical component of the University of Colorado Anschutz Medical Campus.

The University of Colorado offers a comprehensive benefits package that includes health insurance, life insurance, retirement plans, tuition benefits, ECO pass, paid time off – vacation, sick, and holidays and more. To see what benefits are available, please visit: https://www.cu.edu/employee-services/benefits-wellness .

Diversity and Equity:

The University of Colorado Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities, persons within the LGBTQ+ community and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

Qualifications:

Minimum Qualifications:  

Applicants must meet minimum qualifications at the time of hire.  

• Education: Ph.D, M.D., or its equivalent experience.
• Experience:
• 3 or more years of laboratory experience relating directly to HLA molecules and their binding properties, molecular cloning, flow cytometry, and cell assays.
• 3 or more years of laboratory experience in animal anesthesia and surgery, genotyping and breeding mice, tissue collection and database management of a mouse colony. 

Preferred Qualifications:

• Ph.D or MD with Licentiate degree in Medical Pharmacology, immunology, molecular and cellular biosciences, or a related field. 

Knowledge, Skills and Abilities:

• Experience in expression of soluble molecules and production of tetramers
• Experience in CRISPR/Cas9 modification of cells
• Experience with transgenic mouse models and in vivo experiments
• Experience with assay development and performance of molecular biology assays
• Experience with purifying, culturing and expanding mouse and human CD4+ T cells in various disease models
• Experience with administering, training, and mentoring 

How to Apply:

For full consideration, please submit the following document(s):

Applications are accepted electronically ONLY at www.cu.edu/cu-careers .

Questions should be directed to: Tina Roark, christina.roark@cuanschutz.edu  

Screening of Applications Begins:

Screening begins immediately and continues until 10/30/2023.  

Anticipated Pay Range:

The salary for this position has been established as:

$80,000

The above salary range (or hiring range ) represents the University’s good faith and reasonable estimate of the range of possible compensation at the time of posting. This position is not eligible for overtime compensation unless it is non-exempt.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

Total Compensation Calculator: http://www.cu.edu/node/153125

ADA Statement:

The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at hr.adacoordinator@ucdenver.edu ​.

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

Vaccination Statement:

CU Anschutz strongly encourages vaccination against the COVID-19 virus and other vaccine preventable diseases . If you work, visit, or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz, you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work, visit, or volunteer, respectively. In addition, if you work in certain research areas or perform certain safety sensitive job duties, you must enroll in the occupational health medical surveillance program .