Job Summary:

This Instructor-level position is within the Sagerstrom laboratory in the Section of Developmental Biology in the Department of Pediatrics at the University of Colorado – Anschutz Medical Campus. The Instructor will operate with a high degree of independence to carry out bench research examining transcriptional control of cell fate decisions during early embryogenesis using zebrafish as an animal model system. The Instructor will be responsible for independently designing, executing, interpreting and trouble-shooting experiments involving standard molecular, biochemical and genetic methods, as well as standard bioinformatics analyses. The Instructor will also collaborate with existing core facilities to carry out transcriptomic and epigenomic single cell experiments and to analyze the resulting data. The Instructor will assist in the training and advising of graduate students and postdoctoral fellows and will regularly update Dr Sagerstrom on progress towards research goals.

Key Responsibilities:

• Participate in the design of research projects
• Develop and implement new research protocols
• Carry out research projects independently
• Trouble-shoot and problem-solve as needed
• Tabulate research data and keep a detailed laboratory notebook
• Interpret experimental results
• Carry out animal experimentation (zebrafish) as related to research project (generating transgenic and mutant lines, chemical treatments)
• Prepare tissues, cell cultures, etc. for testing
• Perform standard molecular biology methods (cloning, PCR)
• Perform standard biochemical methods (Western blots, IP, gel electrophoresis)
• Perform standard imaging analysis (immunostaining, RNA-FISH)
• Develop and maintain research databases
• Apply standard bioinformatics tools to analyze genomic (ChIP-seq, RNA-seq) data
• Other duties as assigned by Dr Sagerstrom 

Communicate research results (10%):

• Present results at lab meetings
• Present results at project meetings such as research in progress talks
• Present results at (inter)national meetings
• Write and publish manuscripts describing results
• Prepare grant applications, as necessary
• Other duties as assigned by Dr Sagerstrom 

Assist in training and mentoring (10%):

• Train and advise graduate students and postdoctoral fellows in the use of experimental techniques
• Other duties as assigned by Dr Sagerstrom 

Why Join Us:

The Sagerstrom research group is part of a highly cohesive academic unit in the Section of Developmental Biology within the Department of Pediatrics. The Section of Developmental Biology is committed to research that improves child health with five main objectives:

• Understand the genetic, molecular and cellular mechanisms that guide normal development
• Determine how normal developmental processes are altered to result in developmental disease and disability
• Identify new diagnostic strategies and molecular and cellular therapies targeted at treatment of childhood disease
• Train the next generation of leaders in developmental and stem cell biology and pediatric disease research
• Serve as a hub for basic and translational child health research that spans the Anschutz Medical Campus research community

To accomplish these objectives the faculty, graduate students, postdoctoral trainees and research staff who comprise the Section of Developmental Biology perform research using stem cell, organoid and animal experimental models, including Drosophila, zebrafish and mice. Our investigations focus on several major tissue and organ systems such as the brain, heart, intestine, face and vascular, olfactory and immune systems. Our work is leading to a better understanding of childhood disabilities associated with neuropsychiatric disease, Down syndrome, the congenital basis of cardiovascular and facial malformations and the impact of maternal health on fetal development.

The University of Colorado offers a comprehensive benefits package that includes health insurance, life insurance, retirement plans, tuition benefits, ECO pass, paid time off – vacation, sick, and holidays and more. To see what benefits are available, please visit: https://www.cu.edu/employee-services/benefits-wellness .  

Diversity and Equity:

The University of Colorado Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities, persons within the LGBTQ+ community and all veterans. The University of Colorado is committed to diversity and equality in education and employment.  

Qualifications:

Minimum Qualifications:

Applicants must meet minimum qualifications at the time of hire.  

·     Doctoral degree in cell biology, developmental biology, biochemistry, molecular biology, computational biology, genetics, or a related degree.

• 2 years of postdoctoral experience in cell biology, developmental biology, biochemistry, molecular biology, computational biology, genetics, or a related field. 

Preferred Qualifications:  

• Three or more years of postdoctoral experience in developmental biology, computational biology, genetics, or a related field.
• Experience with executing and analyzing single cell RNAseq, MultiomeSeq or related methods.
• Experience generating transgenic and mutant zebrafish lines using CRISP/Cas9, TOL2 transgenesis or related methods.
• Experience with Gateway cloning 

Knowledge, Skills and Abilities:

• Proficient knowledge of basic laboratory techniques including safety procedures and techniques
• Ability to communicate effectively, both in writing and orally
• Ability to establish and maintain effective working relationships with employees at all levels throughout the institution
• Demonstrated commitment and leadership ability to advance diversity and inclusion
• Ability to interpret and master complex research protocol information 

How to Apply:

For full consideration, please submit the following document(s):

Applications are accepted electronically ONLY at www.cu.edu/cu-careers .

Questions should be directed to: charles.sagerstrom@cuanschutz.edu  

Screening of Applications Begins:

Immediately and continues until 5 days after posting.

Anticipated Pay Range:

The salary for this position has been established at:

$75,000

The above hiring salary represents the University’s good faith and reasonable estimate of the range of possible compensation at the time of posting. This position is not eligible for overtime compensation unless it is non-exempt.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

Perks & Benefits: https://www.cu.edu/cu-careers/perks/anschutz-medical-campus

Total Compensation Calculator: http://www.cu.edu/node/153125

ADA Statement:

The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at hr.adacoordinator@ucdenver.edu ​.

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

Vaccination Statement:

CU Anschutz strongly encourages vaccination against the COVID-19 virus and other vaccine preventable diseases . If you work, visit, or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz, you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work, visit, or volunteer, respectively. In addition, if you work in certain research areas or perform certain safety sensitive job duties, you must enroll in the occupational health medical surveillance program .