A fully-funded postdoctoral position is available immediately in the McEachron laboratory in the Pediatric Oncology Branch to study the tumor microenvironment of pediatric sarcomas, with an emphasis on bone tumors. Our goals are to characterize and functionally investigate the tissue-specific sarcoma microenvironments to identify and validate novel therapeutic approaches for subsequent clinical translation, reveal the mechanisms by which tumor cells influence the phenotype and function of both immune and non-immune cells, and stratify patient specimens based on microenvironmental profiles.
Our laboratory is utilizing cutting edge technologies to answer some of the most challenging and clinically relevant questions related to the sarcoma microenvironment including single nuclei sequencing, spatial transcriptomics, spatial proteomics, CRISPR-mediated genome engineering.
Current projects include: Targeting region-specific immunosuppressive pathways in metastatic osteosarcoma to improve the efficacy of cellular therapy, and Investigating the non-cell autonomous effects of somatic alterations in the osteosarcoma genome on the tumor microenvironment.
We are an interdisciplinary laboratory dedicated to resolving the complexity of the tumor microenvironment of childhood solid tumors. We are a highly collaborative group with active collaborators in academia, industry, and with other groups in the NCI. We highly value all aspects of diversity (racial, ethnic, nationality, gender, training background, etc.) and strive to create a productive and inclusive training environment to maximize everyone’s potential. We leverage the robust and unique infrastructure and resources of the intramural research program of the National Institutes of Health to accomplish our research goals and career objectives.

We are seeking highly motivated and creative individuals with a demonstrated depth of knowledge in cancer biology, immunology, immuno-oncology, genomics, and/or molecular biology to join our team. Successful applicants must have excellent organizational skills, the ability to manage multiple projects, proven capabilities to work independently as well as in a team, and excellent communication skills in written and spoken English. A desire to learn and acquire new skillsets is essential. Preferred, but not required skills include experience with analyzing and/or interpreting “-omic” data, murine models, immunohistochemistry, competency in R/python , and/or microscopy. PhD or equivalent is required.

Please submit your CV/Resume and a summary of research experience to Rebecca Shim (Rebecca.Shim@nih.gov )

The NIH is dedicated to building a community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.