The Neuro-Oncology Branch, a trans-institute program of the National Cancer Institute and the National Institute of Neurological Disorders and Stroke of the National Institutes of Health is seeking an outstanding candidate to work in its Molecular and Cell Biology Program. The position involves investigating the unique metabolic phenotype and molecular signaling in brain tumors. The research aims to systematically explore epigenetic changes in oncometabolite-driven cancers, characterizing critical epigenetic targets within DNA repair, metabolism, and therapy resistance pathways, utilizing genetic and biochemical approaches. The mechanistic findings will be verified through in vitro and in vivo models, patient-derived specimens for validation, and experimental therapeutics designed based on preliminary findings. These findings provide strong justifications for future clinical translation and application.

Our laboratory is committed to supporting postdoctoral trainees' scientific career development, commensurate with the level of demonstrated achievements, offering a unique research opportunity in an emerging field with critical basic and translational implications.

To qualify, the successful candidate must possess a Ph.D. degree, preferably in biochemistry, molecular biology, genetics, or a related field, be nearing completion of degree requirements, and have no more than five years of postdoctoral research experience.

The ideal candidate should be able to:

• Be highly motivated, able to conduct semi-independent research, and work effectively within an interdisciplinary team.
• Gather and analyze data and develop new ideas that promote current research.
• Prepare data summaries, reports, manuscripts and presentations of research results.
• Participate/assist in manuscript writing for publication in scientific journals and/or presentation; may assist in grant writing.
• Keep informed of developments in the field to maintain and enhance professional expertise.
• Perform lab maintenance, including maintaining equipment and ordering supplies, as needed.
• Teach techniques to, train, and mentor junior research staff.
• Have strong expertise in cell biology, molecular biology, and next-generation sequencing, with direct expertise in mRNA sequencing, ChIP seq, ChIP cut and run, and ChIP cut and tag assays.
• Have direct expertise in cell cycle-related research, such as synchronization, microscopy, and flow cytometry detection.
• Master routine laboratory techniques, such as cell culture and transfection, DNA cloning and subcloning, and site-directed mutagenesis.
• Have excellent communication skills and fluency in both spoken and written English.

Please email curriculum vitae, statement of research interests, and three letters of reference to the attention of: Chunzhang Yang, Ph.D., Neuro-Oncology Branch, National Cancer Institute, 37 Convent Drive, Room 1142E, Bethesda, MD 20892 at chunzhang.yang@nih.gov .

Candidates may be U.S. citizens, resident aliens, or nonresident aliens.

The NIH is dedicated to building a community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.