St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state-of-the-art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.

A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate the proteins of the innate immune system biochemically and structurally.  We are particularly interested in assessing proteins involved in innate immune responses and cell death (NLRs, caspases, inflammasomes, and inflammatory cell death, PANoptosis).  Please see the following articles:

Cell (2023) [Epub ahead of print]

Science Immunology (2022) 7(74):eabo6294.

Nature (2021) 597(7876):415-9.Cell (2021) 184(1)_149-168.e17.

Cell (2020) 181(3):674-687.e13.

Nature (2019) 573(7775):590-4.

Nature Microbiology (2019) 4(2):316-27.

Cell (2018) 173:1–14.

Journal of Experimental Medicine (2018) 215(4):1023-34.

Nature (2016) 540:583-7.

Science Immunology (2016) 1(2):aag204-5.

The ideal candidate will have experience with biochemical and biophysical methodologies, such as:

• Protein purification
• Protein tagging and expression in multiple cell lines, including baculovirus and mammalian expression system experience
• Cryo-EM
• Mass spectrometry sample preparation pipelines
• Protein-protein interaction studies
• Co-immunoprecipitation experiments

The laboratory of Dr. Thirumala-Devi Kanneganti  offers a remarkable training environment for postdoctoral fellows focused on the innate immune system, including an opportunity to collaborate with researchers in the departments of Immunology, Structural Biology, Infectious Diseases, and cancer biology. Generous salary support and a benefits package that includes professional development funds for journal subscriptions and travel to meetings are available. St. Jude Children's Research Hospital has state-of-the-art facilities including core laboratories for proteomics, metabolomics, RNAseq, transgenic/knock-out technology, and animal facilities.

Candidates should have a recent PhD, DVM, MD/PhD in biomedical sciences, ideally Biochemistry, Structural Biology, or Immunology, and must be hard working and highly motivated. 

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