Postdoctoral positions are available in the laboratory of Dr. Stacey Ogden at St. Jude Children’s Research Hospital to research mechanisms of Sonic Hedgehog signaling during development. We are particularly interested in understanding how Sonic Hedgehog ligands use specialized filopodia called cytonemes to travel from their sites of synthesis to activate signaling on distantly localized target cells. Other focus areas in the laboratory include investigations centered on how Sonic Hedgehog signaling is activated in signal-receiving cells and how GLI transcriptional effectors are regulated to ensure appropriate transcriptional responses occur downstream of ligand. We use genetic model systems and cutting-edge imaging technologies to interrogate these fascinating cell biological questions. Prior experience with mouse models and confocal microscopy is preferred, but not required.

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