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<!--anchor--> <!--anchor--> Post-Doctoral Fellow Cell and Tissue Genomics (CTG) <!--anchor-->

Genentech

Job Description


The Position

The Position

We are looking for a highly motivated researcher, who is passionate about making scientific discoveries that have the potential to impact human health, for a joint Postdoctoral Fellowship in the Riggi and Li labs at the Cellular and Tissue Genomics Department (CTG) within Genentech. This Postdoctoral Fellow will lead projects that will advance our understanding of the role of oncogenic transcription factors (TFs) in cancer, and will deploy new single cell multiomics, spatial transcriptomics and image-based technologies to identify new therapeutic strategies targeting the function of selected TFs. This position will be co-mentored by Drs. Riggi and Li.

The successful applicant will have an opportunity to collaborate across multiple groups whose expertise spans different scientific disciplines and approaches, including cancer immunology, molecular/discovery oncology, computational biology, and biochemistry. The applicant will also have access to our cutting-edge research campus, equipped with the most advanced biomedical, experimental, and computational technologies. Scientific insights resulting from this research are expected to be presented at scientific conferences and published in high impact journals. Opportunities for the clinical translation of new discoveries are also in place.


Responsibilities:

  • Lead the experimental direction of projects and collaborate with a computational Postdoc (To-be-hired in another job ad) to move the projects forward.
  • Initiate and foster intra- and inter-departmental collaborations that will accelerate


Qualifications:

  • Candidates must have a PhD graduate in molecular, cellular, or cancer biology, or a related biological or biomedical science. 
  • Have solid technical skills. Experience with mammalian cell lines and lentiviral vectors, -omics technologies (single cell, CRISPR) and microscopy are highly desired.
  • Be technically rigorous, curious and creative. Show enthusiasm in tackling complex biological problems and vigorous scientific logics.
  • Have advanced at least one key research project as evidenced by a first author paper published or accepted in a respected peer-reviewed journal.
  • Have excellent communication skills and a collaborative and collegial mindset.

For information about the Postdoctoral Program at Genentech, please go to: https://www.gene.com/careers/university-and-early-career/postdocs

Riggi Lab

Nicolo Riggi is  a Sr. Principal scientist and the Director of the CTG-Oncology group within the Department of Cellular and Tissue Genomics. His lab focuses on the identification of the epigenetic mechanisms driving malignant transformation, as well as intratumoral heterogeneity in different cancer types. The Riggi's laboratory is particularly interested in understanding the initial deregulation of epigenetic transcriptional programs allowing the transformation of permissive cell of origin, and the subsequent development of intratumoral heterogeneity fostering tumor progression, relapse and resistance to therapy. The Riggi’s group utilizes a translational approach involving cutting-edge single cell, spatial transcriptomics  and epigenetic technologies to identify clinically relevant new therapeutic targets and biomarkers that can lead to a rapid bench-to-bed translation of the most impactful findings. Nicolo Riggi received his MD from the University of Lausanne in 2001. During his MD-PhD training  at the University Hospital of Lausanne, in the Department of Experimental Pathology, under the supervision of Ivan Stamenkovic he focused on the molecular underpinnings driving cellular permissiveness toward selected oncogenes, and on how different cell states and differentiation trajectories affect the ability to initiate tumor formation by different oncogenic events. In 2009 he joined the Department of Clinical Pathology, where he started his residency in general pathology, and in 2011 he moved to the MGH in Boston for a Research Fellowship, where he combined clinical training in Pathology with a PostDoc in cancer epigenetics in the labs of Brad Bernstein and Miguel Rivera. In 2015 he was appointed as Assistant Professor in the Department of Experimental Pathology at University Hospital of Lausanne, where during 7 years he combined primary 3D tumor models with cutting-edge epigenetic and single cell technologies to understand how genetic, epigenetic and microenvironmental factors influence tumor progression and heterogeneity, with the goal to identify new strategies that can blunt tumor aggressiveness. 

Li Lab

Dr. Li is Principal Scientist in the Department of Cellular and Tissue Genomics. His lab focuses on single-cell multiomics and spatial omics data analysis and tool development, with applications to oncology. Dr. Li is a leading expert in analysis and tool development for large-scale high-throughput genomics data. He developed RSEM, a gold standard tool for transcript quantification from bulk RNA-Seq data. The RSEM papers have been cited 15,582 times (Google Scholar) and the tool itself has been used by big consortia projects such as ENCODE (ENCyclopedia Of DNA Elements), TCGA (The Cancer Genome Atlas), GTEx (Genotype-Tissue Expression) and TOPMed (Trans-Omics for Precision Medicine). His more recent work, Cumulus, is the first comprehensive cloud-based analysis engine for single-cell RNA-seq and was published in Nature Methods (impact factor 47.99). Prior to joining Genentech, Dr. Li was Assistant Professor of Medicine at Harvard Medical School, Assistant Investigator of Massachusetts General Hospital, and Associate Member of the Broad Institute of MIT and Harvard. He did his Ph.D. in Computer Science from the University of Wisconsin-Madison and completed two postdoctoral training with Lior Pactor at UC Berkeley and Aviv Regev at the Broad Institute respectively. For more details, please visit Li Lab website at https://lilab-bcb.github.io/ .


@lib75@gene.com Hi Bo! I accepted your edits and added the description of my lab. Let me know your thoughts.

_Assigned to Bo Li_

The expected salary range for this position based on the primary location of California is $64,800 and $120,500.  Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  This position also qualifies for the benefits detailed at the link provided below.

Benefits


Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote.  If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.


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