The Sontheimer Lab, in the Department of Neuroscience at the University of Virginia (UVA) School of Medicine invites applications for a Research Scientist.  This is an NIH supported position that will investigate the role of extracellular matrix/PNN in acquired epilepsies in a highly collaborative research group.

Sontheimer Lab at the University of Virginia provides an ideal place for doing research with cutting-edge technologies in neuroscience research. A group of more than 15 researchers from across the globe, who are at various career stages including undergraduates, graduates, medical, postdocs, and senior scientists with diverse backgrounds and expertise, provide a welcoming and growth-supportive environment. The state-of-the-art laboratory is equipped with multiple surgery suites, patch clamp electrophysiology rigs, live cell/tissue fluorescence imaging, confocal microscopy, cell/tissue culture, animal behavior and genetic manipulation facility, two-photon imaging of live mouse brain, 24x7 EEG and video monitoring facility to provide uninterrupted workflow in a fast-paced working environment.

Principle Investigator Dr. Sontheimer has a long-standing interest in the mechanisms and therapeutics of neurodegenerative diseases and acquired epilepsy with a current focus on the role of glial cells and extracellular matrix. Besides being a keen researcher, Dr. Sontheimer is a passionate educator and mentor who has trained numerous scientists and students in several disciplines of neuroscience research.   

The project involves looking at the fundamental contribution and molecular mechanisms associated with the extracellular matrix (ECM) and perineuronal nets (PNNs) in the pathogenesis of acquired forms of epilepsy. Previous and ongoing studies from the laboratory show a complex presentation of ECM and PNNs in different models of epilepsy leading us to propose a multifaceted role of ECM and plausible interactions with neuron and glial cells in CNS diseases. Using a combination of techniques including but not limited to patch clamp electrophysiology, newly developed advanced EEG probe, confocal microscopy, and genetic manipulations, the candidate will perform experiments, analyze and present data, and oversee the daily operations related to the project and report PI on regular basis. 

The following expertise is desirable:

• Experience in EEG and/or EMG
• Slice or single-cell electrophysiology
• Small animal surgery
• Mouse handling
• Immunohistochemistry
• Confocal microscopy
• Western blotting

While the position is supported by grants to Dr. Sontheimer, the nature of the position will allow for considerable independence and growth including submission of independent grants. The individual will work closely with a range of trainees including undergraduates graduates and postdocs.

Starting salary will be commensurate with experience but in the $80,000-$90,000 range. 

Required Qualifications:     

Ph.D. in neurobiology, neuroscience, physics, engineering or similar fields.

3+ years postdoctoral experience

The candidate is expected to have a successful research record as demonstrated by publications in peer-reviewed journals.

This position is located in Charlottesville, VA.

This is a restricted position; continuation is dependent on funding and satisfactory performance.

This position will remain open until filled.  The University will perform background checks on all new hires prior to employment.  A completed pre-employment health screen is required for this position prior to employment. 

 To Apply:

Please apply through Workday , and search for R0043994.  Complete an application online with the following documents:

• CV
• Cover letter/statement of interest
• Contact information for 3 references

Upload all materials into the resume submission field, multiple documents can be submitted into this one field. Alternatively, merge all documents into one PDF for submission. Internal applicants must apply through their UVA Workday profile by searching 'Find Jobs'.

For questions about the application process, please contact Jessica Russo, Recruiter, at sxv9zv@virginia.edu .

For more information about UVA and the Charlottesville community please see http://www.virginia.edu/life/charlottesville and https://embarkcva.com/ .

COVID Vaccination Requirement and Guidelines

Please visit the UVA COVID-19 Job Requirements and Guidelines  webpage prior to applying for current information regarding vaccination requirements?and?guidelines for employment at UVA.

The University of Virginia, i ncluding the UVA Health System which represents the UVA Medical Center, Schools of Medicine and Nursing, UVA Physician’s Group and the Claude Moore Health Sciences Library, are fundamentally committed to the diversity of our faculty and staff.  We believe diversity is excellence expressing itself through every person's perspectives and lived experiences.  We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information.