The position

We are looking for a talented and highly motivated postdoctoral fellow to join my group in the Department of Structural Biology at Genentech to study the function and regulation of macromolecular assemblies important in fundamental cellular processes and human disease.
The position is available immediately and fully funded for up to four years. The postdoc will have the unique opportunity to work in a highly collaborative research environment on diverse projects such as investigating T cell receptor signaling and the regulation of kinetochore assembly and function. The postdoc will be able to independently pursue projects and grow their expertise in X-ray crystallography, cryo-EM and cryo-ET, with access to state-of-the-art lab equipment, high resolution cryo-EM technology and a virtually unlimited computer cluster for data processing.
The Department of Structural Biology at Genentech is a scientifically rich and highly stimulating research environment that has a strong track record in mentoring postdocs and collaborating with other research groups at Genentech and in the academic community.
Who you are:

• Completed or in the last year of a Ph.D. in structural biology, biochemistry or a related field of research.

• Demonstrated expertise in protein purification, biophysical characterization and structure determination by X-ray crystallography and/or single-particle cryoEM of multi-protein complexes as shown by a strong record of first-author publications in high quality journals.

• Experience in protein engineering, biophysical characterization methods for protein-protein and protein-nucleic acid interactions, such as surface-plasmon resonance (SPR), Isothermal Titration Calorimetry (ITC), or bio-layer interferometry (BLI) and in vitro assay development will be beneficial.

• Self-motivated and detail-oriented, driven to solve complex scientific problems independently and in a collaborative environment.

• Strong oral and written communication skills are required.

If interested and have questions, please contact me directly (dimitrova.yoana at gene.com) and provide a copy of your CV.

#postdoc

#LI-TS5

Relocation benefits are available for this job posting.

For more information about the Dimitrova's Lab:

https://www.gene.com/scientists/our-scientists/yoana-dimitrova

More Information about the Genentech Postdoctoral Program:
http://www.gene.com/careers/academic-programs/postdocs

Relevant publications:

Hamilton GE, Helgeson LA, Noland CL, Asbury CL, Dimitrova YN, Davis TN (2020) Reconstitution

reveals two paths of force transmission through the kinetochore. eLife.

Migl, D, Kschonsak M, Arthur CP, Khin Y, Harrison SC, Ciferri C, Dimitrova YN (2020) Cryoelectron microscopy structure of a yeast centromeric nucleosome at 2.7 Å resolution. Structure. 28, 363-370.

Dimitrova YN, Jenni S, Valverde R,  Khin Y, Harrison SC (2016)  Structure of the  MIND  complex defines a regulatory focus for yeast kinetochore assembly. Cell. 167(4): 1014-1027

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